摘要
目的 探讨老年冠心病患者代谢指标与肱动脉舒张功能间的相关性。 方法 检测老年冠心病患者、老年健康者、非老年健康者的代谢指标并采用高分辨彩色超声技术检测肱动脉舒张功能 :反应性充血后血管舒张 (FMD)、含服硝酸甘油后的血管舒张 (NID)并进行分析。 结果 (1)老年冠心病组的甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)、血尿酸 (SUA)的水平显著高于老年和非老年健康组 (均为P <0 0 5 ) ,高密度脂蛋白胆固醇(HDL C)水平显著低于老年和非老年健康组 (均为P <0 0 5 ) ,上述指标在两健康组间无差异 ;(2 )老年冠心病组的FMD(4 44± 1 17) %显著低于老年健康组和非老年健康组 [分别为 (6 90± 1 47) %和 (10 5 1± 1 78) % ,P <0 0 1] ,非老年健康组的FMD显著高于老年健康组 (P <0 0 1) ;(3 )年龄、TG、SUA、与FMD呈负相关 (分别r =-0 70 ,-0 2 9和 -0 46,均P <0 0 5 ) ,HDL C与FMD呈正相关 (r=0 2 8,P <0 0 5 ) ;(4 )体质量指数 (BMI)、LDL C、SUA与TG呈正相关 (r =0 2 7,0 2 7和 0 3 4,均P <0 0 5 )。 结论 老年冠心病患者存在血脂、SUA等代谢紊乱和血管内皮功能障碍 ,其中依赖性血管舒张功能障碍随增龄而加重 ,并与TG、HDL C、SUA及老年冠心病间有显著相关性 ,SUA水平可?
Objective To investigate the relationship between metabolism indexes and vasodilation of brachial artery in elderly patients with coronary heart disease(CHD). Methods The metabolism indexes were detected and brachial artery flow mediated vasodilation(FMD)was measured by high resolution ultrasound technique in 30 elderly patients with CHD,27 cases of healthy elderly subjects,12 cases of healthy non-elderly subjects. Results (1)The triglyceride(TG),low-density lipoprotein (LDL-C),serum uric acid(SUA) level in elderly CHD patients were significantly higher than those in healthy elderly group and healthy non-elderly group( P <0.05),while high-density lipoprotein(HDL-C) level in elderly CHD patients was significantly lower than that in the other two groups( P <0.05),There was no difference between two healthy groups;(2)The FMD in elderly CHD patients[(4.44±1.17)%]was significantly lower than that in the other two groups[(6.90±1.47)% and (10.51±1.78)%,all P <0.01],The FMD in healthy non-elderly group was significantly higher than healthy elderly group ( P <0.01);(3)Negative correlation was showed between FMD and age,TG and SUA( r=-0.70,-0.29 and -0.46,P<0.05 respectively).Positive correlation was showed between FMD and HDL-C( r=0.28,P<0.05); (4)Positive correlation was showed between TG and BMI,LDL-C and SUA( r=0.27,0.27 and 0.34, P<0.05 respectively). Conclusions The elderly CHD patients presented with metabolic abnormality(such as blood lipid and serum uric acid etc.)and endothelial vasodilation dysfunction.The vasodilation dysfunction becomes severe while the age increased.The BMI,TG,HDL-C and SUA has the significant correlation with endothelial vasodilation function and the elderly CHD.the level of SUA may be a sign of endothelial vasodilation impairment or one of the indirect risk factors.
出处
《实用老年医学》
CAS
2004年第2期86-88,共3页
Practical Geriatrics
