摘要
背景:中医治疗偏头痛方法较多,其中针刺治疗偏头痛的疗效显著,往往收到针到痛止之奇效,故值得进一步研究。目的:明确针刺治疗偏头痛的临床疗效,并探讨针刺治疗偏头痛的生化学机制。设计:以诊断为依据的病例对照研究。地点、对象和干预:将63例偏头痛患者按随机抽签法分为针刺组(32例)和对照组(31例),观察临床疗效及治疗前后血中血小板活化因子(plateletactivatingfactor,PAF),血栓烷B2,6-酮-PGF1α含量,并选择20例健康人作为正常对照组。主要观察指标:针刺对偏头痛症状的作用和对其血中PAF,血栓烷B2,6-酮-前列腺素F1α含量的影响。结果:针刺治疗对偏头痛疗效明显,总有效率达90.6%,优于对照组(χ2=3.9459,P<0.05);偏头痛患者在治疗前血中PAF、血栓烷B2、6-酮-前列腺素F1α含量均高于正常对照组(t=6.416～13.144,P<0.01),而针刺组在治疗后血中PAF、血栓烷B2、6-酮-前列腺素F1α含量犤(18.13±1.90)μg/L,(99.65±36.43),(20.71±4.65)ng/L犦低于对照组犤(22.41±2.44)μg/L,(130.56±49.74),(29.67±6.78)ng/L犦(t=2.807～7.752,P<0.01)。结论:针刺治疗偏头痛疗效明显;PAF、血栓烷B2、6-酮-前列腺素F1α均参与偏头痛的病理过程,针刺对偏头痛患者血中PAF、血栓烷B2、6-酮-前列腺素F1α有调节作用。
BACKGROUND:Acupuncture therapy is a kind of remarkable curative means of Traditional Chinese Medicine(TCM) in the treatment of migraine,and the pain can often be alleviated as soon as the needle is inserted. Consequently,it is worth making further study. OBJECTIVE:To study the clinic effect and the biochemical mechanism of acupuncture in the treatment of migraine. DESIGN:Case control study on the basis of diagnosis. SETTING,PARTICIPANTS and INTERVENTION:Totally 63 patients with migraine were enrolled and divided into 2 groups at random:acupuncture group(32 cases) and control group(31 cases).The effect of the acupuncture therapy was observed after treatment,and the levels of PAF,TXB2,and 6 keto PGF1αin the plasma of the patients were observed before and after treatment.Besides,20 healthy volunteers were selected as normal controls. MAIN OUTCOME MEASURE:The effect of the acupuncture on the symptoms of migraine and the influence of it on the levels of PAF,TXB2 and 6 keto PGF1α. RESULTS:Obvious therapeutic effect was gained for migraine , the effect was better than that of the control group(χ2=3.9459,P< 0.05),and the total effective rate was 90.6%.For the patients with migraine,the levels of PAF,TXB2 and 6 keto PGF1αwere higher before treatment as compared with those of the normal control group(t=6.416-13.144, P< 0.01).After treatment, the levels of them in the acupuncture group[(18.13±1.90)μg/L (99.65±36.43),(20.71±4.65) ng/L] were lower in comparison with those of the control group[(22.41±2.44)μg/L,(130.56±49.74),(29.67±6.78)ng/L](t=2.807-7.752,P< 0.01). CONCLUSION: PAF,TXB2 and 6 keto PGF1αall have relations to the pathogenesis of migraine and can be adjusted by acupuncture.
出处
《中国临床康复》
CAS
CSCD
2004年第10期1994-1995,共2页
Chinese Journal of Clinical Rehabilitation
基金
哈尔滨市学科后备带头人基金项目(9971218034)~~
