摘要
目的:研究不同年龄和注意状态下事件相关电位的变化特点。方法:智能正常的年轻和老年男性各15人,2×2析因设计,采用odd-ball模式,利用NicoletPathfinderⅡ型诱发电位仪,记录主动分辨靶刺激时,计数/不计数状态下事件相关电位各波潜伏期和P3波幅的变化。结果:年龄和注意状态对N1,P2潜伏期无显著影响,但对N2潜伏期犤年轻人计数(215.9±28.1)ms与不计数(229.4±39.2)ms;老年人计数(253.2±29.2)ms与不计数(281.1±46.2)ms犦,P3潜伏期犤年轻人计数(270.7±33.1)ms与不计数(274.3±42.9)ms;老年人计数(308.0±45.0)ms与不计数(345.1±51.2)ms犦和P3波幅犤年轻人计数(5.5±2.3)μV与不计数(2.6±1.2)μV;老年人计数(3.7±2.0)μV与不计数(2.5±1.3)μV犦均有明显的影响。在老龄和不计数状态时N2潜伏期出现明显的延长而P3波幅明显下降。P3潜伏期只受年龄的影响,注意状态对其无显著作用。年龄和注意状态对N2,P3潜伏期和P3波幅的影响不存在交互作用。结论:P3波幅与衰老和注意密切相关,P3潜伏期不易受被试注意力的影响,是一个稳定的测量认知功能的指标。
AIM:To study the modified characteristics of event related potentials(ERPs) under different age and attention condition. METHODS:A 2×2 factorial design was adapted in this study.According to auditory oddball paradigm different wave latencies of ERPs and P3 amplitudes recorded by Nicoler Pathfinder II in 15 healthy young men and 15 old men with active attention to target stimulation in counting or uncounting manner. RESULTS:Age and active attention had no influence on the latencies of N1 and P2,but played a significant role in the latencies of N2[(215.9±28.1) ms and(229.4±39.2) ms for the young men and(253.2±29.2) ms and(281.1±46.2) ms for the old men respectively]and P3 [(270.7±33.1) ms and(274.3±42.9) ms for the young men and(308.0±45.0) ms and(345.1±51.2) ms for the old men respectively] and the amplitudes of P3 [(5.5±2.3) μV and(2.6±1.2) μV for the young men and(3.7±2.0) μV and(2.5±1.3) μV for the old men respectively] for the young and old subjects respectively in the manners of counting and uncounting.The latencies of N2 were significantly prolonged while the amplitudes of P3 was reduced significantly in the old subjects and the subjects in the manner of uncounting.Only age had remarkable influence on the latency of P3.And there was no interaction between age and attention condition on the latencies of N2 and P3 and the amplitude of P3. CONCLUSION:P300 amplitude is closely related with aging, and latency of P3 is difficultly affected by the attention of subjects,which is regarded as a stable marker for measuring cognitive function.
出处
《中国临床康复》
CSCD
2004年第10期1826-1827,共2页
Chinese Journal of Clinical Rehabilitation
基金
军队"十五"重点课题(01Z037)~~
