摘要
目的 探讨胸膜腔内注入尿激酶、氟美松对结核性渗出性胸膜炎所致胸膜肥厚和包裹性积液的影响。方法 6 7例结核性粘连包裹性胸膜炎患者随机分为尿激酶组 (36例 )和氟美松组 (31例 )。尿激酶组于每次抽液后注入尿激酶 10 0 0 0 0 IU ,氟美松组于每次抽液后注入氟美松 5 mg。结果 尿激酶组抽液总量 (310 9± 4 39) ml,而氟美松组 (2 80 5± 4 30 ) m l(P<0 .0 1) ;尿激酶组胸膜厚度 (0 .81± 0 .2 3) mm,而氟美松组 (1.12± 0 .2 4 ) mm(P<0 .0 1) ;尿激酶组胸膜粘连的发生率为 11% ,而氟美松组为 39% (P<0 .0 1)。结论 胸腔内注入氟美松虽能减少胸水形成 ,但在降低胸膜肥厚和粘连发生机会和程度方面不如尿激酶。
Objective To investigate the effects of intrapleural urokinase and corticosteroids in the prevention of pleural thickening and loculated pleural effusion.Methods Sixty-seven patients with tuberculous pleural effusions were randomized into 2 groups: GroupⅠ and GroupⅡ. The patients in GroupⅠ were injected with urokinase 100,000 IU intrapleurally after each thoracocentesis twice a week, while the patients in GroupⅡ were injected with corticosteroids 5 mg. Results The mean volume of the fluid drained in GroupⅠ was (3,109±439) ml, while it was (2,805±430) ml in GroupⅡ (P<0.01). The mean thickness of pleura in GroupⅠ was (0.81±0.23)mm, but it was (1.12±0.24)mm in GroupⅡ (P<0.01). The incidence of pleural adhesion and loculation in GroupⅠ was 11%, but it was 39% in GroupⅡ (P<0.01).Conclusion Although intrapleural corticosteroids can greatly decrease the volume of pleural effusion drained, it can not prevent pleural thickening and adhesion. Intrapleural urokinase can prevent pleural thickening and adhesion.
出处
《临床肺科杂志》
2004年第1期35-36,共2页
Journal of Clinical Pulmonary Medicine
