摘要
硝苯地平(nifedipine)治疗病态窦房结综合征(SSS)21例(男14例,女7例),平均年龄46.5岁,剂量多数为60mg/d,(少数为90～120mg/d),服药4周后复查窦房结电生理参数(SNRT及CSNRT)以及基础心率等,较安慰剂对照期明显改善(P均<0.001),昏厥及黑朦发作以及低心输出量综合征等均消失,本组结果提示硝苯地平对SSS确具一定疗效(包括急及慢性效应)。
Sick sinus syndrome (SSS) is actually a manifestation of hypodynamic circulation, and one of the main side effects of deloading agents is hyperdynamic circulation, whether the latter might totally or partially offset the former was investigated. The effect of nifedipine on 21 patients (14 males, 7 females, 28～67 years old) with SSS was studied. Nifedipine was given orally in a dose of 30～120 mg/day (followed up for 6～38 months). Heart rate was increased (p<0.001), SNRT and CSNRT were shortened(p<0.001). All symptoms such as syncope, presyncope, etc. disappeared. The results revealed that both short-term and long-term effects of nifedipine on patients with SSS were relatively good in improving symptoms and sinus function.
出处
《中国循环杂志》
CSCD
1992年第5期438-439,共2页
Chinese Circulation Journal
