摘要
连续对50例动脉导管未闭(PDA)手术以硝酸甘油、硝酸甘油复合维拉帕米或普萘洛尔施行控制性降压。结果表明,硝酸甘油、硝酸甘油复合维拉帕米或普萘洛尔降压,具有快速、安全、血压易于控制、无耐药性、能即刻停药等的优点,尤其在减少术后高血压反跳方面,明显优于硝普钠。
The hypotensive effects of nitroglycerin (NTG),nitroglycerin combined with intravenous isoptin or propranolol were studied in 50 patients for surgical correction of patent ductus arteriosus (PDA). The patients were randomly divided into 3 groups: (1) NTG combined with isoptin 0.05～0.2 mg·kg^(-1)(n=20); (2) NTG combined with propranolol 0.01～0.02 mg·kg^(-1)(n=10);(3) NTG infusion only (n=20).The results showed that in all of the 3 groups systolic blood pressure was lowered to about 10.6 kPa, but the maximal minute doses of NTG were reduced by 81.4% in group 1 and by 65.7% in group 2 compared to that in group 3 (17.2±5.44μg·kg^(-1)·min^(-1)). The heart rates were not increased in all patients during bypotension. Episodes of hypertension were found in only 5 cases (10%) postoperatively and they were treated with sodium nitroprusside (SNP).It is concluded that NTG, NTG supplemented with isoptin or propranolol for the induction of hypotension during PDA operation are efficient and safe. It is much better than SNP in reducing the morbidity of postoperative hypertension.
出处
《中国循环杂志》
CSCD
1992年第5期453-456,共4页
Chinese Circulation Journal
关键词
动脉导管未闭
硝酸甘油
高血压
Patent ductus arteriosus
Controlled hypotension
Nitroglycerin
Isoptin
Propranolol
Postoperative hypertension
