摘要
本文对21例充血性心力衰竭患者随机分为可乐定治疗组和对照组,观察神经体液因素和血液动力学的长程疗效。结果表明:可乐定可降低血浆去甲肾上腺素、肾素活性和血管紧张素Ⅱ的水平,减轻心脏负荷,降低心肌氧耗,增加每搏输出量,从而改善大多数心力衰竭患者的心功能状态,具有良好的长程血液动力学效应。
Twenty-one cases of congestive heart failure (CHF) were divided into clonidine treatment group (n=13) treated with clonidine 0.3～0.45mg/day for 4 weeks and control group (n=8). All patients were under conventional CHF therapy (digoxin, but no diuretics and vasodilators). Plasma norepinephrine (NE), plasma renin activity (PRA), angiotensin Ⅱ(AT Ⅱ) and hemodynamic data were determined before and after treatment. After clonidine, plasma NE, PRA and AT Ⅱ were decreased significantly as compared to those before treatment, while HR, SBP, DBP and double products, MPAP and PCWP were decreased markedly (p<0.01), SV and SVI wern increased (p<0.05) either compared to those of controls or before clonidine. Average cardiac function grade (NYHA) reduced from 2.9 to 2.0 but no change had been found in controls. Thus the data show that stimulation of central alpha 2 adrenoceptors by clonidine effectively inhibits sympathetic overactivity, improves hemodynamic status and cardiac function without seriousadverse effects. Clonidine is effective and safe fortreatment of most cases of congestive heart failure.
出处
《中国循环杂志》
CSCD
1992年第3期240-242,共3页
Chinese Circulation Journal
关键词
可乐定
充血性
心力衰竭
神经体液
Clonidine
Congestive heart failure Neurohumoral
Hemodynamics
