摘要
双盲法观察到,卡托普利(巯甲丙脯酸)可改善充血性心力衰竭(下简称心衰)并稀释性低钠血症者的心肾功能、运动耐量及临床症状,矫正低血钠及水潴留。治疗后血浆血管紧张素Ⅱ的降低及前列腺素E_2、I_2的升高与血钠升高相关良好。并用呋喃苯胺酸可提高疗效。
We studied the effect of captopril on dilution hyponatremia in 31 patients with severe congestive heart failure by a randomized, double-blind and placebo-controlled method. Four week captopril treatment could significantly improve the cardio-renal function, exerelse tolerance and clinical symptoms in those patients, and yet hyponatremia and water retention which had been refractory to diuretics were corrected. A good corre- lation was found between the decrease in plasma angiotensin Ⅱ (A Ⅱ) and the increase in serum sodium. The prostaglandins E_2, and I_2, (PGE_2, PGI_2,) also had positive correlations with serum sodium. Captopril and small dose furosemide in combination was even more effective than captopril alone. The correction of hyponatremia by captopril was mainly through the inhibition of RAS and the stimulation of PGE_2, and PGI_2, which lead to the improvement of cardio-renal function with diuresis and natriuresis (more diuresis than natriuresis).
出处
《中国循环杂志》
CSCD
1992年第2期146-149,共4页
Chinese Circulation Journal
关键词
心力衰竭
低钠血症
卡托普利
Congestive heart failure
Hyponatremia
Captopril
Prostaglandin
