摘要
本实验观察到活性氧自由基(光照虎红酸钠,RB),在低浓度(RB:10^(-6)M)时,有增加豚鼠乳头肌收缩幅度和出现自发收缩的效应;在高浓度时(RB:10^(-5)～10^(-4)M),显著地增加乳头肌静息张力,以致出现“挛缩”。设想这可能与细胞损伤及胞内钙离子异常有关。
It is known that photoactivation of rose bengal (RB) can produce activated oxygen intermediates——mainly singlet oxygen and small amount of hydroxyl free radical.We observed that illuminationof low concentration of RB (10^(-6)M)in the bath could enhance contraction amplitude of papillary muscle of guinea pig heart by 248.7% of the control and evoke spontaneous contractions. Resting tension of papillary muscle showed significant increase(eventually approaching 'rigor'). No contraction was found when concentration of RB in the bath reached 10^(-5) M-10^(-4) M and even after 30min washing. It is thus speculated that myocardial injury might be initiated directly by activated oxygen intermediates and related to the increase of intracellular calcium load.
出处
《中国循环杂志》
CSCD
1992年第1期58-60,共3页
Chinese Circulation Journal
关键词
活性氧
豚鼠
乳头肌
心肌损伤
Activated oxygen
Guinea pig
Papillary muscle
Contractility
Myocardial injury
