摘要
本组高血压病患者62例,同时测定血和尿β_2微球蛋白(β_2-MG)含量及常规肾功能指标尿素氮(BUN)、肌酐(Cr)、内生肌酐清除率(Ccr),旨在评价高血压患者血和尿β_2-MG浓度改变对早期肾功能损害的诊断意义。调查表明,高血压患者血清和尿液β_2-MG阳性率显著高于血清Cr和BUN(P<0.01),并且与Cr、BUN成正相关,(r=0.634、0.8),与Ccr成负相关,(r=-0.939)。随着病程长、病情重,血、尿β_2-MG明显升高,Ⅲ期患者血、尿β_2-MG显著高于Ⅰ、Ⅱ期(0.05>P>0.01)。本组病例中还发现在Cr、BUN、Ccr正常患者中血、尿β_2-MG已升高。以上提示β_2-MG不但可以反映高血压患者肾功能的变化,而且可以较早预示肾功能的损害,可能是测定高血压患者肾功能减退的一个较敏感的指标。
To evaluate the diagnostic significance of changes of β_2-microglobulin (β_2-MG) in serum and urine for early renal involvement in patients with essential hypertension (EH), 62 patients of EH were studied, including 14 cases of hypertension grade-Ⅰ, 33 of grade-Ⅱ and 15 of grade-Ⅲ. β_2-MG in serum and urine was determined by radioimmunoassay, blood urea nitrogen (BUN), creatinine (Cr) and creatinine clearance (Ccr) were determined also. The results showed that 53.2% of the patients had increased both serum and urine β_2-MG. Increased serum and urine β_2-MG were 7.1% and 14.2% for grade-Ⅰ, 54.5% and 51.5% for grade-Ⅱ, 100% and 86.7% for grade-Ⅲ respectively. The correlation coefficients between β_2-MG and Cr, BUN, Ccr were 0.800, 0.634 and 0.939 respectively (P<0.01), Serum β_2-MG increased in 21 out of 51 patients with normal Cr (41.2%), 16 out of 44 patients with normal BUN (36.4%), and urinary β_2-MG increased in 11 out of 30 patients with normal Ccr (36.7%).
The data indicates that the increase of β_2-MG in essential hypertensive patients might be due to hypertension with concomitant renal arterial sclerosis and renal function impairment. Blood β_2-MG might be more sensitive in reflecting hypertensive impairment of renal function than BUN, Cr and Ccr.
出处
《中国循环杂志》
CSCD
1992年第1期21-23,共3页
Chinese Circulation Journal
关键词
Β2微球蛋白
高血压
肾功能
β_2-Microglobulin
Hypertension
Renal function
