摘要
用荧光法测定74例充血性心衰(CHF)患者血浆5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NE)含量。结果显示,CHF时各项值均显著高于对照组,5-HT值在心功能Ⅳ级>Ⅲ级>Ⅱ级,相互间差异显著。心功能改善后,5-HT、5-HIAA值比NE下降显著。5-HT含量持续并逐渐升高的CHF患者则预后差。
Seventy-four cases of congestive heart failure of various degrees (CHF) and 50 cases of healthy subjects were studied for changes in plasma 5-HT (5-hydroxytryptamine), 5-HIAA (5-hydroxyindoleacetic acid) and NE (norepinephrine). It was found that: 1. Plasma levels of 5-HT, 5-HIAA and NE in CHF group were higher than those in healthy controls (P<0.001); 2. The increase in plasma levels of 5-HT was most prominent in NHYA class Ⅳ cases, moderate in class Ⅲ and less significant in class Ⅱ (P<0.05—0.01); 3. After control of CHF, plasma levels of 5-HT and 5-HIAA were significantly decreased (P<0.001), NE remained still high; 4. In the dead cases, plasma 5-HT level was markedly higher than that in the survivals (P<0.001). However, no definite correlation could be found in plasma NE. It is concluded that plasma level of 5-HT might be used to evaluate cardiac function, therapeutic effect and prognosis in CHF.
出处
《中国循环杂志》
CSCD
1992年第1期33-35,共3页
Chinese Circulation Journal
关键词
充血性
心力衰竭
5-羟色胺
Congestive heart failure
5-Hydroxytryptamine
5-Hydroxyindoleacetic acid
