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番茄红素对大鼠细胞DNA氧化损伤修复的影响 被引量：18

Effect of lycopene on DNA oxidative damage of cells in rats
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摘要 目的　研究番茄红素对大鼠淋巴细胞和肝细胞DNA损伤的保护作用。方法　大鼠灌胃番茄红素 4周后 ,采用单细胞凝胶电泳技术对外周血淋巴细胞和肝细胞DNA损伤进行分析。结果　番茄红素组大鼠淋巴细胞和肝细胞DNA的迁移率和尾长显著低于对照组。结论　番茄红素对淋巴细胞和肝细胞DNA损伤具有一定的保护作用。 Objective Observe the protective effect of Lycopene(LP) on DNA damag. Methods Rats were given LP after 4 weeks,the DNA break in peripheral blood lymphocytes and liver cells from the rats were analyzed with single cell gel electrophoresis. Results Compared with control, the damage of DNA in LP group were reduced significantly( P <0 05). Conclusion LP could protect DNA damage of peripheral blood lymphocytes and liver cells in rats.
作者 潘洪志 那立欣 石刚 李省三 王德才 曹军
机构地区 哈尔滨医科大学公共卫生学院 黑龙江省教师体育学院 齐齐哈尔医学院
出处 《卫生研究》 CAS CSCD 北大核心 2004年第2期189-191,共3页 Journal of Hygiene Research
基金 黑龙江省十五攻关课题 (No.ZB0 2B4 0 2 - 1)
关键词 番茄红素 大鼠 DNA损伤 单细胞凝胶电泳 Lycopene, rat,DNA damage,single cell gel electrophoresis
分类号 Q562 [生物学—生物化学] Q523 [生物学—生物化学]
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参考文献8

  • 1Nguyen ML,Schwartz SJ.Lycopene stabilility during food rocessing.Proc Sooc Exp Biol Med,1998,218:101
  • 2Sies H,Stabl W.Vitamins E and C,β-carotene,and other carotenoids as antioxidants.Am J Clin Nrtr,1995,62:s1315-s1321
  • 3Vladimir K,Makoto Ao,Nobuo T,et al.Differential dose dependent effects of α,β-carotenes and lycopene on gap unctional intercellular communication in rat liver in vivo.Jpn J Cancer Res,1997,88:112-114
  • 4Rao AV,Agarwal S.Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer.Nutr Cancer,1998,31 (3):199-203
  • 5Porrini M,Riso P.Lymphocyte lycopone concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption.J Nutr,2000 Feb,130(2):189-192
  • 6Riso P,Pinder A,Santangelo A,et al.Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? Am J Glin Nutr,1999,69(4):712-718
  • 7Breinholt V,Lauridsen ST,Daneshvar B,et al.Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat.Cancer Lett,2000 ,154(2) :201-210
  • 8潘洪志,石刚,陈文华,王德才.番茄红素对大鼠体内抗氧化系统功能的影响[J].卫生研究,2003,32(5):441-442. 被引量：48

二级参考文献9

  • 1Sies H, Stahl W. Vitamins E and C, β - carotene, and other carotenoids as antioxidants. Am J Clin Nrtr, 1995,62:1315S-1321S.
  • 2Vladimir Kmtovskikh, Makoto Asamom, Nobuo Takasuka, et al. Differential dose dependent Effects of α,β-carotenes and lycopene on gap junctional intercellular communication in rat liver in vlvo. Jpn J Cancer Bes, 1997, 88:112-114.
  • 3Rao AV, Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer, 1998,31(3) : 199-203.
  • 4Agarwal S, Rao AV. Tomato lycopene and low density lipoprotein oxidation:a human dietary intervention study. Lipids, 1998, 33 (10) :981-994.
  • 5Simon Giavarotti KA, Rodrigues L, Rodrigues T, et al. Liver microsomal parameters related to oxidative stress and antioxidant systems in hyperthyroid rats subjected to acute lindane treatment. Free Radic Res, 1998,29( 1 ) : 35-42.
  • 6Breinholt V, Lauridsen ST, Daneshvar B, et al. Dose-response effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat. Cancer Lett,2000, 30,154(2) :201-210.
  • 7Rust P, Lehner P, Elmadfa I. Relationship between dietary intake, antioxidant status and smoking habits in female Austrian smokers. Eur J Nutr, 2001,40(2) :78-83.
  • 8Porrini M, Riso P. Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. J Nutr, 2000,130(2) : 189-192.
  • 9Riso P, Pinder A, Santangelo A, et al. Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative domage? Am J Clin Nutr, 1999 ,69(4) :712-718.

共引文献48

同被引文献124

引证文献18

二级引证文献97

卫生研究
2004年 第2期

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