摘要
目的 分析13 1I治疗甲亢后发生早发甲状腺功能减低 (甲减 )的转归及与转归有关的因素。方法 6 1例甲亢经13 1I治疗后的早发甲减患者 ,随访 1年以上 ,根据随访结果分为暂时性甲减组 (包括转为正常或甲亢者 )和永久性甲减组 ,比较了两组间早发甲减的出现时间、性别、TGA和TMA、甲状腺重量、13 1I治疗剂量、甲状腺摄碘率峰值。结果 6 1例患者中有一半以上为暂时性甲减 (3 3%转为甲亢 ,5 0 4 %转为正常 )。根据甲减出现的时间不同分为≤ 3个月、4～ 6个月、>6个月 ,13 1I治疗 6个月后出现的甲减均为永久性甲减。其他参数与早发甲减的转归无关。结论 早发甲减绝大多数为暂时性甲减 ,甲减出现的时间可能与其转归有关。
Objective To evaluate the development of early hypothyroidism of patients with hyperthyroidism after radioiodine131 therapy, its outcome and predisposing factors. Methods Sixty-one patients manifesting early hypothyroidism after treatment with 131 I were followed-up for over one year, and they were divided into two groups: temporary hypothroidism group (including those who had attained normal thyroid function and those with recurrent hyperthyroidism), and permanent hypothyroidism. The duration between treatment and appearance of hypothyroidism, gender, thyroglobulin antibody (TGA) and thyroid microsome auto-antibody (TMA) levels, thyroid weight, total dosage of 131 I, and peak of 131 I intake were compared between two groups. Results Over one half of the 61 patients manifested temporary hypothyroidism (3.3% with recurrent hyperthyroidism, 50.4% of them attained normal thyroid function). Based on the length of the interval between the beginning of the treatment and onset of hypothyroidism, they could be categorized into ≤3 month, 4～6 months became permanent hypothyroidic. The above indises determined during the treatment did not show relationship with the outcome. Conclusion It was therefore concluded that the time of appearance of hypothyroidism was the main factor which determined the outcome of 131 I therapy so far as hypothyroidism was concerned.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2004年第2期168-169,共2页
Medical Journal of Chinese People's Liberation Army
