摘要
[目的]探讨超选择性髂内动脉插管化疗对中晚期宫颈癌的疗效。[方法]经皮股动脉穿刺插管。在数字减影血管造影下(DSA),对61例(81例次)中晚期宫颈癌进行超选择性髂内动脉及肿瘤供血动脉插管化疗,其中20例宫颈癌患者介入前后使用流式细胞仪进行DNA含量(DI)测定和S期细胞比率(SPF)以及细胞凋亡的检测,另30例宫颈癌患者介入前后取宫颈活检组织检测核仁组成区嗜银蛋白(AgNOR)、增殖细胞核抗原(PCNA)的表达。[结果]介入治疗近期有效率为78.7%,症状缓解有效率为88.5%,手术治疗46例,栓塞组术中出血量明显低于未栓塞组(P<0.05);介入化疗后的DI、SPF均显著低于化疗前(P<0.05);介入化疗后的AgNOR颗粒数目减少、直径增大(P<0.05),介入化疗后PCNA的积分减少(P<0.05)。[结论]①中晚期宫颈癌经超选择性血管介入治疗获得根治手术机会明显增加;动脉化疗-栓塞治疗效果优于动脉化疗;提示未经治疗的宫颈癌患者为血管介入化疗最佳适应证。②介入化疗能降低其DNA含量和S期细胞比率,抑制宫颈癌细胞增殖,诱导细胞凋亡,抑制肿瘤的恶性进展。③超选择性髂内动脉插管化疗为一种微创、可重复进行、安全、有效的治疗措施。
To investigate the efficacy of superselection internal ilia artery catheterization chemotherapy(SIAC)in advanced cervical carcinoma.SIAC with Seldinger catheterization and DSA was performed in16cases(81times)with advanced cervical carcinoma.Using flow cytometry,we determined DNA content and S-phase fraction(SPF)and apoptosis in cervical carcinoma pre-and postchemotherapy.Short-term response rate was78.7%.Symptom remission rate was88.5%.Forty-six cases received operation following SIAC.The amount of bleeding during operation was significantly lesser in embolized group than that in non-embolized group.[Conclusion]The superselection internal ilia artery catheterization chemotherapy can apparently increase the chance of operation in advanced cervical carcinoma.SIAC is a new,safe and effective treatment.
出处
《肿瘤学杂志》
CAS
2004年第2期78-81,共4页
Journal of Chinese Oncology
关键词
介入疗法
宫颈癌
intraarterial therapy
cervical neoplasms
