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正交试验优化手性镍催化不对称反应条件研究

OPTIMIZING THE CHIRAL NICKEL-CATALYZED ENANTIOSELECTIVE REACTION BY ORTHOGONAL EXPERIMENT METHOD
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摘要 用正交试验法优化手性镍催化二乙基锌对α,β不饱和酮的不对称麦克尔加成反应条件,优化后的不对称麦克尔加成反应的一般条件为:低温(近反应溶剂冰点),常压,非质子非极性溶剂(环己烷). Based on the new research results of enantioselective catalysis mechanism and the principle of ligand-accelerated catalysis,a general lab method for the reactive condion selection is discussed.System orthogonal experiment method was firstly applied to optimize the title reaction.The method is standardized and programmed and has the characteristics of convenience and reliability.It suits to be used in lab.The common conditions for this reaction after selection include lower temperature (accessing to solvent's (m.p.),)atmosphere,non-protonic and non-polar solvent (hexane).
作者 王恒山 杨燕 童碧海 谢建武 潘英明
机构地区 广西师范大学化学化工学院天然产物研究与开发重点实验室 玉林师范学院化学与生物系
出处 《广西师范大学学报（自然科学版）》 CAS 2004年第1期69-73,共5页 Journal of Guangxi Normal University:Natural Science Edition
基金 广西青年基金资助项目(桂青科0229023) 广西教育厅基金资助项目
关键词 正交试验 镍 不对称麦克尔加成反应 不对称催化 优化 手性分子 enantioselective michael addition enantioselective catalysis orthogonal experiment method optimization
分类号 O614.813 [理学—无机化学] O621.34 [理学—有机化学]
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参考文献19

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广西师范大学学报（自然科学版）
2004年 第1期

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