摘要
目的 探讨阿司匹林对老年人结肠癌手术前后组织中前列腺素E2(PGE2)含量的影响。方法 采用放免法测定 组织匀浆中PGE2含量。对老年人结肠癌术后病例分为阿司匹林治疗组及谷参肠胺对照组,随访12个月,观察两组复发率。 结果 治疗前老年人结肠癌组(57例)病变组织中PGE2含量(245.33±22.32pg／mg)明显高于其病变相邻正常结肠粘膜组织中 的PGB含量(89.32±35.34pg／mg)(P<0.01)。术后6个月及12个月,老年人结肠癌阿司匹林治疗组复发率(3／29,6／29) (10.3％,20.7％)明显低干谷参肠胺对照组(7／28,12／28)(25.0％,43.0％)(P<0.05)。结论老年人结肠癌组织中PGE2含 量明显高于正常粘膜组织中PGE2含量。阿司匹林通过抑制PGE2的合成,减少老年人结肠癌术后结肠组织中PGE2含量,与降 低老年人结肠癌的术后复发率可能有一定的关系。
Objective To prove the change of content of PGE2 in tissues of old colon carcinoma after operation.Methods The content of PGE2 in colon mucosa had been determined by radioimmunoassay. The old patients of colon carcinoma after operation had been divided into the treated group and the control group . The treated group patients(n=29) was administered with aspirin 0.3g, tid,for 12 months, the control group patients(n=28) was administered with Gushenchangan 0.8,tid,for 12 months. Results The PGE2 content in tissue of colon carcinoma (245.33±22.32pg/mg tissue)were higher than that in normal colon tissue(89.32±35.34 pg/mg tissue) , (P<0.01) . The recurrence rate of colon carcinoma of elderly in aspirin treated group (10.3% ,20.7%)were lower than that in control group(25% ,43%) in 6 and 12 months after operation. Conclusions The PGE2 content in tissues of colon carcinoma of elderly was higher than that in normal colon tissue . Aspirin has likely some effects to prevent the recurrence of colon carcinoma of elderly after operation and inhibits the PGE2 synthesis in tissues of colon carcinoma of elderly.
出处
《解放军保健医学杂志》
2004年第1期22-24,共3页
Journal Of Health Care And Medicine in Chinese Pla
