摘要
目的分析经侵袭性垂体腺瘤侵袭性的判断标准及其与临床预后的关系。方法回顾性分析我科自2000年1月至2003年5月行经蝶手术切除的具有完整影像学、病理学和随访资料的侵袭性垂体腺瘤82例,随访时间5～30个月。结果侵袭性垂体腺瘤MR影像学特点为鞍底受侵下陷,部分肿瘤突入蝶窦;颈内动脉包绕;海绵窦受累,鞍隔突破等。病理检查以鞍底硬膜浸润的发生率最高。PRL腺瘤的全切率明显低于无功能腺瘤(P<0.01),无功能腺瘤、GH腺瘤与ACTH腺瘤之间相差不明显。PRL腺瘤的复发率较无功能腺瘤和GH腺瘤高(P<0.05)。结论垂体腺瘤的侵袭性生物学行为导致手术全切几率下降,是术后复发的主要原因。
Objective To analyse the standard of estimation for the invasive pituitary adenoma invasiveness and relationship between it and clinical prognosis of the patients with invasive pituitary adenoma. Methods The imaging, pathological and follow-up data of 82 patients with invasive pituitary adenoma, who underwent transsphenoidal surgery from Jun 2000 to May 2003 in our department, were analysed retrospectively. The follow-up time ranged from 5 to 30 months. Results MRI findings of invasive pituitary adenoma included invasion of the sella turcica and adjacent bones, involvement of sphenoid sinus and cavernous sinus, adenema wrapping the internal carotid artery, etc. Pathological examination showed that the invasion rate of dura in sella turcica was the highest among that of structures around the tumor. The total removal rate for PRL-secreting adenomas was significantly lower than that for non-secreting adenomas (P<0.01). And the differences among non-, GH-, ACTH-secreting adenomas were significant. The recurrence rate of PRL-secreting adenomas was higher than that of non- and GH-secreting adenomas (P<0.05). Conclusion Invasive biological behaviors of invasive pituitary adenomas result in radical operation failure and postoperative recurrence.
出处
《中国临床神经外科杂志》
2004年第2期90-92,共3页
Chinese Journal of Clinical Neurosurgery
