摘要
应激性高血糖可使脑梗死溶栓治疗后有症状出血率增高,影响溶栓治疗的效果。应激性高血糖通过加重脑组织内乳酸堆积,增加自由基形成和兴奋性氨基酸的产生等多种途径加重缺血性脑损伤。其作用受梗死范围、部位和局部血液循环情况等多种因素的影响。目前是否应用胰岛素降低应激性高血糖,降低到什么程度合适尚无统一标准,建议在脑梗死患者入院后24 h内避免静脉输注葡萄糖溶液。
Stress hyperglycemia can increase the risk of symptomatic hemorrhage after thrombolytic therapy in cerebral infarction and decrease the efficacy of thrombolysis. Stress hyperglycemia can increase the formation of free radical and the production of excitatory amino acids through various paths exacerbating lactic acid accumulation in brain tissues and aggravating ischemic brain injuries. Its role is influenced by various factors, such as the size, the location of cerebral infarction and the status of blood circulation, etc. Whether insulin should be used currently in reducing stress hyperglycemia and to what extent is appropriate has no unified standards. It is suggested that intravenous glucose should be avoided in patients with cerebral infarction within the first 24 hours after admission.
出处
《国外医学（脑血管疾病分册）》
2004年第4期298-300,共3页
Foreign Medical Sciences Cerebrovascular Diseases
