摘要
取新西兰雄性白兔,用合成饲料进行高脂喂养。自5周起,分批测定主动脉根部的血压和流量,测定至11周结束。另取健康常规喂养兔子以相同方法测定,作为正常对照组。测定后剥离自颈动脉至股动脉的动脉树,进行组织学检查。按动脉粥样硬化分级标准,取1～2级为轻度硬化组,3～4级作为重度硬化组,对动脉零压顺应性C_0和特征阻抗Zc进行统计。结果:1.正常组C_0=0.089±0.011;轻度硬化组C_0=0.054±0.013;重度硬化组C_0=0.040±0.014。轻度硬化组与对照组之间有极显著性差异(P<0.01),重度硬组与轻度硬化组之间有显著性差异(P<0.05)。2.正常组Zc=1.64±0.49;轻度硬化组Zc=2.36±0.68;重度硬化组Zc=2.94±0.87;各硬化组均与正常组之间有显著性差异(P<0.05),但二硬化组之间无差异。
<ABSTRACT>
To assess whether atherosclerosis affects hemodynamics, we fed
some New Zealand white rabbits on a high cholesterol diet and some on
common diet. After 5 wks, the aortic pressure and blood flow of rab-
bit were measured. Then the arterial compliance C was calculated by
stroke volume and pressure curve according to the nonlinear Windkessel
model for the arterial system. And characteristic impedance Zc was ob-
tained from Fourier analysis. After measurement, the rabbits were kil-
led and the arterial tree from carotid to femoral was isolated, fixed and
stained for lipid with Sudan Ⅲ Aoccording to standard atherosclerosis
classification, grade 0 was treated as control, grade 1-2 and grade 3-4
were treated as mild and severe atherosclerosis groups respectively. The
statistical results were: 1. There were no difference between the groups
in mean arterial pressure, stroke volume, heart rate and total peripheral
resistance. 2. Arterial compliance C decreased with atherosclerotic
severity (minor vs. control, P <0.01; severe vs. minor,P<0.05). 3. Imp-
edance Zc increased with atherosclerotic severity. (minor vs. control,
P<0.05; severe vs. minor, ns. ).
These results indicated that even early atherosclerosis affects the
arterial compliance and characteristic impedance.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
1992年第4期219-228,共10页
Chinese Journal of Biomedical Engineering
基金
国家"七.五"攻关项目"动脉粥样硬化机理研究"的一部分
关键词
动脉粥样硬化
血液动力学
疾病模型
: Arterial wall property
Impedance
Compliance
Atheroscletosis
Windkessel model
