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胎儿腮腺内瘦素和瘦素受体免疫组织化学观察 被引量：1

Immunohistochemical observation of the leptin and its receptor in the parotid gland of human fetus
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摘要 目的　观察胎儿腮腺内瘦素和瘦素受体的表达、分布及发育规律。方法　HE染色法和免疫组化SABC法。结果　胎儿腮腺纹状管、小叶间导管上皮细胞呈瘦素及瘦素受体免疫反应阳性 ,免疫反应产物分布于导管上皮细胞胞质内 ,细胞核呈阴性反应。在胚胎发育的不同阶段 ,免疫反应强度亦不等。结论　胎儿腮腺内有瘦素和瘦素受体表达 ,可能参与调节胎儿腮腺和胃肠的发育及功能活动。 Objective To study the expression,distribution and development regularity of leptin and its receptor in the fetal parotid gland. Methods HE staining and immunohistochemical SABC methods were used. Results The epithelial cells of striated and interlobular ducts showed leptin and its receptor immunoreactivity. The immunocomplexes distributed in the epithelial cytoplasm of the ducts. Nuclei were negative. The immunoreactive intensity was unequal at different embryonic stages of fetal parotid gland. Conclusion Leptin and its receptor was present in fetal parotid gland, which may be involved in the fetal parotid gland and gastrointestinal development and the functional regulation.
作者 伍雪芳 彭彦霄 柯红林 王惠珠 贾雪梅
机构地区 安徽医科大学组织学与胚胎学教研室
出处 《安徽医科大学学报》 CAS 2004年第2期113-115,共3页 Acta Universitatis Medicinalis Anhui
基金 安徽省教育厅自然科学基金资助课题 (编号 :2 0 0 1kj12 3
关键词 胎儿 腮腺 瘦素 瘦素受体 免疫组织化学 proteins immunohistochemistry parotid gland fetus
分类号 R322.25 [医药卫生—人体解剖和组织胚胎学] R977.6 [医药卫生—药品]
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参考文献7

  • 1Ur E, Wilkinson DA, Morash BA et al. Leptin immunoreactivity is localized to neurons in rat brain. Neuroendocrinology, 2002;75(4):264～72
  • 2De Matteis R, Puxeddu R, Riva A et al. Intralobular ducts of human major salivary glands contain leptin and its receptor. J Anat, 2002;201(5):363～70
  • 3郭启煜,高妍.瘦素的信号转导机制[J].国外医学（分子生物学分册）,2002,24(2):105-108. 被引量：9
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共引文献19

同被引文献15

  • 1彭彦霄,伍雪芳,王惠珠,贾雪梅.瘦素及其受体在大鼠下颌下腺的定位研究[J].解剖学报,2004,35(6):640-642. 被引量：3
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  • 6Ur E, Wilkinson DA, Morash BA et al. Leptin immunoreactivity is localized to neurons in rat brain. Neuroendocrinology, 2002;75(4): 264～72.
  • 7Timothy J, Kieffer TJ , Holler RS et al. Leptin suppression of insulin secretion by the activation of ATP-senstive K+ channels in pancreatic β cells. Diabetes,1997;46(6): 1087～93.
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  • 10Miyanaga F,Ogawa Y,Ebihara K et al. Leptin as adjunct of insulin therapy in insulin-deficient diabetes.Diabetologia ,2003;46(10):1329～37.

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安徽医科大学学报
2004年 第2期

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