摘要
本文比较fsepamicin(ISP)、庆大霉素(GM)、地贝卡星(DKB)、乙基西索米星(NTL)、妥布霉素(TOB)、西索米星(SISO)与阿米卡星(AMK)的体外抗菌活性。金葡菌产酶株对上述抗生素的敏感性显较不产酶株为差,以ISP、NTL对金葡菌产酶株的作用最强。其平均MIC值分别为1.85和2.12mg/L;对革兰氏阴性杆菌的作用则以ISP和AMK为强。以ISP对各种细菌的MIC值最低0.32～3.39mg/L。TOB、GM、SISO、NTL与DKB对多数革兰氏阴性杆菌的作用相似,五者之间有很大程度交叉耐药。所测611株革兰氏阴性杆菌中对一种以上药物耐药者312株,占51％;其中对ISP和AMK仍敏感者分别为90.4％和91.7％,而对NTl、GM、TOB、DKB敏感者仅15～18％,本文讨论了细菌对氨基糖苷类的耐药机理及其临床意义。
The in vitro antibacterial activity of seven aminoglycosi-des, Isepamicin (ISP), Gentamicin (GM), Tobramycin (TOB), Netilmicin (NTL),Sisomicin(SISO), Dibekacin(DKB)and Amikacin (AMK), was tested against 713 clinical isolates collected from hospitals in Shanghai. The a-minoglycosides were more active against the enzyme negative Staph. aure- us than the penicillinase producing strains.ISP and AMK were more active than the other antibiotics against 611 strains of gram negative organisms, the MICs of ISP being 2~4 times lower than that of AMK. 312 strains were resistant to one of the aminoglycosides tested, among them 90.4% and 91.7% being susceptible to ISP and AMK.Only about 15~18% of the resistant strains were susceptible to NTL, TOB, GM, DKB and SISO(except. NTL-resistant P. aeruginosa) showing that cross resistance existed among the above antibiotics. Our data suggested that compare with AMK, ISP is 2~4 times more active against sensitive strains, while at least as active against GM and TOB-resistant strains. ISP may play the same role as AMK in hospitals in this country.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1992年第3期179-184,共6页
Chinese Journal of Antibiotics
关键词
氨基糖苷类
细菌耐药性
抗生素
Aminoglycosides
Bacterial resistance
Isepamicin
