摘要
对约氏疟原虫有保护性免疫的BALB/c小鼠,体内注射单抗去除CD^(4+)或CD^(8+)T细胞后,对保护性免疫无明显影响。但将它们脾细胞中CD^(8+)T细胞注入裸鼠,可以转移部分免疫力,而注入CD^(4+)T细胞则不能。在约氏疟原虫感染小鼠模型中,由于在感染早期原虫侵入网织红细胞,CD^(8+)T细胞可被激活而有杀伤作用。在晚期,抗体在免疫中起主要作用。
BALB/c mice which had developed protective immunity against Plasmodium yoelii (P.y.) challenge were injected with anti-CD4 or anti-CD8 monoclonal antibody,and were then challenged again with P.yoelii.No impairment of protection was observed.CD8+T cells obtained from spleens of these mice were transferred to BALB/c nude mice and induced partial protection,while transfer of CD4+T cells did not so.In P.yoelli-mouse model,the parasites invaded reticulocytes in the early infection,and the infected reticulocytes could be recognized and attacked by sensitized CD8+T cells.In late infection when P.yoelii also invaded mature erythrocytes,the protective effect of CD8+T cells decreased and the main role of protection was played by antibodies.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1992年第1期33-36,共4页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金~~
关键词
T细胞亚群
约氏疟原虫
保护性免疫
T cell subsets,Plasmodium yoelii,protective immunity.
