摘要
以日本血吸虫中国大陆株童虫为实验对象,研究比较了嗜酸粒细胞(Eos)的细胞毒效应对抗体和/或补体的依赖作用。正交设计的体外杀伤试验表明补体和抗体均可作为配体参与Eos杀伤日本血吸虫中国大陆株童虫的细胞毒效应作用;配体依赖作用的大小顺序为抗体+补体>补体>抗体;在新鲜免疫血清1∶20、培养48h、效/靶比5000∶1时童虫死亡率最高。
This paper reports the antibody and /or complement dependent eosionphil(Eos) mediated cytotoxicity to chinese strain of Schistosma japonicum. Taking mortality of schistosomula as criteria, orthogonal design shows both C and Ab can act as ligands in mediating Eos dependent damage. The order of intensity of the cytotoxicity is C+Ab>C>Ab. The highest target mortality was obtained when the fresh immune serum(at the dilution of 1:20)was cultivated 48 hours and the effector cell/target was 5000: 1.
出处
《中国寄生虫病防治杂志》
CSCD
1992年第2期117-121,共5页
Chinese Journal of Parasitic Disease Control
