摘要
为从基因水平研究补肾疗法延缓衰老的效果和机理,列举补肾方(右归丸、补肾益寿胶囊)对老年大鼠T细胞凋亡及其相关基因(Fas、FasL),和促凋亡、抗凋亡基因mRNA,T细胞 Caspase 8、Caspase3活性等的影响,并与桃红四物汤比较;以及补肾益寿胶囊对老年人T细胞凋亡和促凋亡基因mRNA的影响。结果:补肾方能有效降低老年大鼠和老年人T细胞的过度凋亡,而这种作用是补肾方对各个相关基因综合调控的结果。为肾本质和中药延缓衰老的研究提出了新的思路。
To study the effects and mechanism of kidney-nourishing prescriptions in delaying senility from the perspective of gene level, this paper presents the effects of different kidney-nourishing prescriptions on T cell apoptosis and its relevant genes (Fas and FasL), auxo-apoptotic genes, anti-apoptotic genes mRNA,and the activities of Caspase 8 and Caspase 3. 'Taohong Siwu Decoction' was also used as control. Results: Kidney-nourishing prescriptions could decrease the excessive apoptosis of T cell in the aged rats and human by regulating all the relevant genes. This gives a new thought for studying the essence of kidneys and for the materia medica to delay senility.
出处
《上海中医药大学学报》
CAS
2004年第1期38-41,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30070907
39870917)
