摘要
单独一种维生素缺乏对免疫功能的影响已有较多研究报道,但维生素缺乏一般不会单独发生,为此本实验研究了维生素A、E、B_2、B_6及叶酸供给不足(1/3生理需要量)、加倍补充(2倍和3倍生理需要量)后对小鼠抗体形成细胞的复合效应。动物喂养6周(不足纠正组喂8周),结果显示,不足组抗体形成细胞显著低于对照组,而2倍、3倍组则显著升高,不足组补充正常量维生素后,抗体形成细胞升高超过对照组,与2倍量组无显著差异;另外,该几种维生素对肝脏RNA、脾脏DNA、RNA及肝脏蛋白质均有明显影响,且抗体形成细胞的变化与核酸、蛋白质含量改变相平行,提示后者可能是维生素作用于体液免疫系统的生化机制。
The previous work merely described the influence of individual vitamin on immunity. In this report, the comprehensive effect of vitamin A,E, riboflavin, pyridoxine and folic acid with insufficient supply (1/3 requirement) or enough supply (double requirement, triple requirement) on antibody forming cell (AFC) was studied in the BALB/C mice. The results showed that the AFC decreased significantly in the 1/3 group and increased phenomenally in 2 time or 3 time group in comparison to the control. The AFC increased markedly and no difference with the 2 time group after insufficient animals fed normal diet for two weeks. Otherwise, the study also found that the vitamin complex had a significant influence on the contents of RNA of the liver,DNA and RNA of the spleen and the protein of the liver, there was a balance relationship between the change of the AFC and the one of contents of nucleic acid or protein. It seems that the abnormity of the metabolism of uncleic acids and protein is the biochemical mechanism of the change of the immune function.
