培哚普利对血压正常老年冠心病患者内皮功能的影响被引量：8

The Effect of Peridopril on Vascular Endothelium Function of Elderly Coronary Artery Diseases Patients with Normal Blood Pressure

暂未订购

导出

摘要目的通过观察培哚普利对老年冠心病患者内皮功能的影响 ,进一步阐明培哚普利通过改善内皮功能发挥其抗动脉粥样硬化的作用 ,为其广泛的临床应用提供理论依据。方法选择血压正常老年冠心病患者100例 ,随机分为常规治疗组 (c组 ,n=50)及培哚普利组(P组 ,n=50) ,运用无创超声检查技术 ,观察用药前后的颈动脉内中膜厚度(IMT)及肱动脉内皮依赖性舒张功能(FMD)的变化 ,同时 ,检测一氧化氮(NO)及内皮素 -1(ET-1)的浓度变化。结果培哚普利治疗后,IMT由(1.12±0.29)mm降至(0.89±0.24)mm ,FMD由(4.51±0.98) %上升为(9.45±0.24) % ,ET由(157.40±62.14)pg/ml降至(105.94±52.83)pg/ml,NO由(45.74±15.35)μmol/L上升至(68.91±20.17)μmol/L ,差异均有显著性意义。结论培哚普利明显改善老年冠心病患者内皮功能 ,具有抗动脉粥样硬化的作用。 Objective To provide theoretic evidences for using peridopril clinically through observing the effect on endothelial function and clarifying the antiatherogenic roles on elderly coronary artery disease patients with normal blood pressure.Methods100elderly coronary artery diseases patients with normal blood pressure were diˉvided into control group,(C group,n=50)and peridopril group(P group,n=50),The non_invasive ultrasonic examination was operated to observe the carotid artery intima_media thickness and brachial artery endothelium_depen_ dent diastolic function of pre_and post_treatment,at the same time,the concentration of ET-1and NO were measured too.Results After therapy with peridopril for half a year,IMTdecreased from(1.12±0.29)mm to(0.89±0.24)mm,FMD increased from(4.51±0.98)%to(9.45±0.24)%,the concentration of ET_1lowered from(157.40±62.14)pg/ml to(105.94±52.83)pg/ml,NO enhanced from(45.74±15.35)μmol/l to(68.91±20.17)μmol/l.Conclusions Peridopril had antiatherogenic role through ameliorating the endothelial function of elderly coronary artery diseases.

作者戚本玲管思明柯琴梅陈汉荣

机构地区华中科技大学同济医学院附属协和医院老年病科

出处《中国微循环》 2004年第2期95-98,共4页 Journal of Chinese Microcirculation

基金湖北省自然科学基金资助项目(编号 :0001 -0112)

关键词培哚普利内皮功能冠心病老年人血压无创超声检查抗动脉粥样硬化 Peridopril Endothelial function Coronary artery diseases Elderly

分类号 R541.4 [医药卫生—心血管疾病] R972.6 [医药卫生—药品]

引文网络
相关文献

参考文献7

1Celermajer DS, Sorensen KE, Gooch VM, et al.No-invasive detection of endothelial dysfunction in children and adults of atherosclerosis[M]. Lancet. 1992,340:111～115.
2Heiss G, Sharret AR, Barrenes R, et al.Carotid arterosclerosis measured by B mode ultrasound in population: association with cardiovascular risk factor in the ARIC study[J] .Am J Epidemic. 1991,134:250～257.
3Todd J A, Akimi U, Marie D, et al. Close relation of endothelial function in the human coronary and peripheral circulations[J] .Am Coll Cardiol.1995,26:1235～1241.
4Ghiadoni L, Virdis A, Magagna A, et al.Effect of the A ngiotensin Ⅱtype 1 receptor blocker candesartan on endothelial fundtion in patients with essential hypertension [J]. Hypertens. 2000, 35: 501.
5Stefano T, Agostino V, Lorenzo G, et al.Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients[J]. Hypertens. 2001,19:1379～1386.
6Thybo NK, Stephens N, Cooper A, et al. Effect of antihypertension treatment onsmall ateries of patients with previously untreated essential hypertension [J]. Hypertens. 1995,25: 474～481.
7Fennessy PA, Campbell JH, Mendelsohn FA, et al. Angiotensin-converting enzyme inhibitors and atherosclerosis: relevance of animal models to human disease[J] .Clin Exp Pharmacol Physiol. 1996,23(8) :30～ 32.