摘要
本实验观察大鼠肾缺血75min及缺血60min后再灌注15min时肾组织脂质过氧化(LPO)和有关酶类变化。结果显示,肾脏缺血和缺血/再灌注后肾皮质和髓质中脂质过氧化产物丙二醛(MDA)含量均显著增高。超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性无明显变化。缺血/再灌注后黄嘌呤氧化酶(XO)活性显著升高。上述结果提示,肾缺血和缺血/再灌注时的LPO增强与氧自由基(OFR)产生增多有关。但上述二种情况时OFR产生机制不尽相同。
The changes of lipid peroxidation in the ischemic (renal artery occlusion for 75 min) and ischemie/reperfusion (renal artery occlusion 60 min plus 15 min reflow) kidney was studied in 19 male SD rats. The results showed that malondialdehydc of renal cortex and medulla was increased, but in both groups SOD and GSH-Px were not changed significantly. Activity of xanthine oxidase activity in the ischemic/reperfusion kidney were increased as compared with normal. These results suggest that lipid pcroxidation was involved in the ischemic and ischemic/reperfusion renal injury, and xanthine-xanthine oxidase might be one of the major sources of oxygen free radical when oxygen supply to ischemic kidney was restored.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1992年第4期354-356,共3页
Chinese Journal of Pathophysiology
关键词
过氧化脂质类
肾
病理生理学
Lipid peroxides
Kidney
Rats
Xanthine oxidase
