摘要
流行性出血热(EHF)灭活疫苗对初免一年或一年半后的25名志愿者加强免疫1针,未发现局部和全身副反应,可使初免后中和抗体阴性者或初免后阳性转阴者,中和抗体全部阳转,且中和抗体几何平均滴度与初免相比有成倍的增长。表明此疫苗的初免是有效的,即使初免后未检出中和抗体,但对EHF病毒抗原仍具有强烈的回亿反应,因而EHF灭活疫苗加强免疫是十分必要的。
No side effects were found locally and generally in 25 volunteers when the s(?)cordary immunization(one injecton) with inactivated EHF vaccine was done at a year or a year and half after primary immunization, The EHF virus antibodies were detected by PRNT in these volunteers who were negative of neutralization antibody at primary immunization or turned negative from positive, The neutralization antibody GMT (geometial meantitre)after secondary immunization is twice as high as that of primary immunization, The above results showed the primary immunization of inactivatated EHFis effective, AIthough the neutralization antibody had not turn positive after primary immunization, the volunteers possess strong anamnestic reaction to EHF antigen,Therefore the secondary immunization is necessary,
出处
《中国病毒学》
CSCD
1992年第4期404-407,共4页
Virologica Sinica
关键词
流行性出血热
灭活疫苗
免疫效果
Inactivated EHF vaccine Human immunization Secondary immunization
