摘要
近年来国内外文献报道,中枢神经系统的催产素(OT)在痛觉调制过程中发挥着一定的作用,我们最近的工作也表明,脑和脊髓内的OT不仅可以提高大鼠的痛阈,而且能明显增强电针镇痛效应。
The effect of oxytocin (OT) and cholecystokinin octapeptide (CCK-8) on EA analgesia was studied in rats. The increase of 20.8—39.8% and 9.0—45.0% in pain threshold was observed respectively when ICV of CCK-8 or naloxone was combined with EA, these increases were lower than that in saline-EA group significantly, while the simultaneous ICV of OT and CCK-8 or OT and naloxone in combination with EA produced the increase of 76.2～116.6% and 41.8～104.5% in pain threshold separately. These results showed that only a small part in the role of OT enhancing EA analgesia was blocked by CCK-8 and naloxone. The data suggest that the role of OT in EA was not entirely dependent upon the endogeous opiate peptides.
出处
《针刺研究》
CAS
CSCD
1992年第2期136-138,共3页
Acupuncture Research
基金
国家自然科学基金
