摘要
目的:检测PDGF-BB在视神经损伤和修复过程中表达的变化。方法:建立大鼠视神经再生模型,免疫组化法检测PDGF-BB在正常视神经和视神经-坐骨神经吻合后不同时段在各组织部位的表达。结果:在大鼠正常视神经,PDGF-BB阴性表达,在视神经-坐骨神经吻合后,视神经PDGF-BB阳性表达,其表达量随病程的发展而变化。结论:坐骨神经移植能够促进视神经的再生,在此过程中PDGF-BB发挥着一定的作用。
AIM: To detect the expression of PDGF-BB in normal and regenerated optic nerves.· METHODS: An optic nerve regenerated model was set up in rats. Immunohistochemistry was applied to detect the expression of PDGF-BB in normal optic nerves and in the regenerated optic nerves with transplanted sciatic nerve in different periods respectively. · RESULTS: The normal optic nerves did not express any PDGF-BB. Whereas the optic nerves expressed PDGF-BB after sciatic nerve transplantation and the expression quantities were various in different periods.· CONCLUSION: Optic nerve can regenerate after sciatic nerve transplantation and PDGF-BB may play an important role in this process.·
出处
《国际眼科杂志》
CAS
2004年第1期65-68,共4页
International Eye Science
基金
中国福建省科技厅重大科研项目资助(No:2000F005)~~
