摘要
本文对聚天冬酰胺以碳酸酯形式键合炔诺酮的共价复合物进行了体外释放试验,研究了此复合物作为缓释体系的可行性,并观察了结合量高低及间隙基的长短对释放行为的影响.证实用柱切换高效液相色谱检测该缓释药物浓度是可靠的.
The in-vitro release of two kinds of biodegradable polymer-norethindrone(NET)conjugates was studied. This buffer was attempted as a releasing medium. The aliquots of the releasing medium were injected into a modified column switching HPLC(CSHPLC) for quantitation. The results indicated the polymers to be a good biodegradable backbone. The releasing rate of NET from the polymer-drug conjugates during the releasing period was constant and uniform. Different spacer length (2C and 3C) and varied NET loading of polymer-drug conjugates showed a little change in the releasing rate.
基金
国家计生委资助项目
关键词
合成
女用避孕药
药代动力学
Long effective contraceptive drug/chem syn
Norethindrone/pharm
Poly (hydroxyalkyl)D, L-asparamine
Contraceptives, oral, synthetic
Contraceptive agent, female
