摘要
目的 :观察苓桂术甘汤对AA大鼠继发性炎症的影响 ,探讨其免疫调节作用机制。方法 :采用CFA诱导AA大鼠模型 ,于造模后第 11dig给药。采用放射免疫法测定用药 10d后非致炎侧后足踝关节液中炎症介质IL - 1β、TNFα及PGE2 等的含量 ,结果 :苓桂术甘汤各剂量均能明显地降低AA大鼠继发性炎症区域IL - 1β、TNFα及PGE2 等的含量 ,减轻AA大鼠致炎后第 2 1、2 6d非致炎侧后足爪肿胀度 (P <0 0 5 )。结论 :苓桂术甘汤对CFA诱导的变态反应性异常免疫具有明显的抑制作用。
Objective:To study the effect of Lingguizhugan decoction on interleukin-1β (IL-1β),TNFα and PGE 2 in concomitantly inflammatory district adjuvant arthritis(AA) rats.Methods:The adjuvant arthritis rats were induced by complete Freund's adjuvant.The content of IL-1β,TNF α and PGE 2 were measured by radioimmunoassay.Results: Lingguizhugan decoction could obviously inhibit the contrast foot swell of AA rats on the 16th,21th days.It could also evidently depress the activity of IL-1β,TNF α and low the content of PGE 2.Conclusion: Lingguizhugan decoction could obviously inhibit arthritic swell,its mechanism may be related to depress the release of IL-1β,TNFα and PGE 2 in rats with abnormal reaction adjuvant arthritis(AA).
出处
《中国中医药科技》
CAS
2004年第2期75-76,共2页
Chinese Journal of Traditional Medical Science and Technology
基金
安徽省教育厅自然科学研究资助项目 (No .2 0 0 0j114 7)
