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电离辐射损伤与DNA修复基因 被引量：5

Damage of ionizing radiation and DNA repair gene
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摘要 DNA辐射损伤直接影响复制、转录和蛋白质合成,进而影响细胞遗传、发育、生长和代谢等生命活动。DNA损伤还是突变的重要原因,而严重的突变可造成细胞癌变,导致肿瘤的发生。然而,生物体内存在着DNA损伤修复系统,其中DNA修复基因起着重要的作用。 DNA damage after exposure to ionizing radiation has a direct effect on DNA replication,transcription and protein synthesis.Further,heredity,development and metabolism of the cells can be affected.DNA damage was an importance factor for mutation of cells,furthermore,carcinogen can be caused by severe mutation.However,there is a DNA repair system in the organism,and especially DNA repair gene plays an important role for DNA damage.This review will briefly present DNA re-pair gene and its function.
作者 张占春
机构地区 宁波市医疗中心李惠利医院肿瘤放疗科
出处 《国外医学（放射医学核医学分册）》 2004年第1期26-29,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金 国家自然科学基金资助项目(39770238)
关键词 电离辐射损伤 DNA修复基因 基因突变 酿酒酵母 肿瘤 radiation damage DNA repair gene radiation-sensitive
分类号 R818 [医药卫生—放射医学]
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参考文献15

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同被引文献29

  • 1王芹.X射线修复交叉互补基因功能的研究进展[J].国外医学（放射医学核医学分册）,2005,29(3):132-136. 被引量：4
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引证文献5

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国外医学（放射医学核医学分册）
2004年 第1期

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