摘要
目的 :观察顽固性咽部溃疡 ( RPU)患者咽部组织粘膜炎细胞的病理意义。方法 :采用组织病理学、免疫组织化学 SP技术随机检测 36例 RPU组溃疡粘膜的 HLA- DR抗原的表达 ,并进行统计学分析。结果 :RPU组溃疡粘膜经组织病理学检查均符合 RPU的诊断 ,病变粘膜中巨噬细胞、T淋巴细胞、上皮细胞、血管内皮细胞异常表达 HLA- DR抗原。结论 :RPU患者溃疡粘膜HLA- DR抗原的异常表达可能在递呈抗原及启动局部免疫过程中起关键作用 ,RPU是一种由T淋巴细胞介导的局部免疫反应。
Objective:To study the relationship between inflammatory cell infiltration in recurrent pharyngeal ulcer (RPU) tissues and pathogenesis. Methods:Pharyngeal mucosa from 5 normal individuals and 36 patients of recurrent pharyngeal ulcer were studied with immunohistochemistry SP technique and histopathological examination. Results:36 cases with RPU were diagnosed and HLA DR Ag was strongly expressed on activated T cells, macrophages,epithelia and vascular endothelia in RPU tissues.Conclusion: The results suggested that the expression of HLA DR antigen may play an important role in the translating antigen and promoting local immunoreaction. RPU was a kind of local immunoreaction which was mediated by T lymphocyte infiltration.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2003年第2期182-184,F001,共4页
Journal of Jilin University：Medicine Edition
