摘要
12名男性健康志愿者一次口服 2 0mg甲巯咪唑片后 ,以HPLC法测定血浆甲巯咪唑浓度 ,用非房室模型参数估算法计算药物动力学参数。主要的药物动力学参数为峰时间 (Tmax) ( 1.5 2± 0 .96)h ,峰浓度 (Cmax) ( 3 91± 77) μg/L ,曲线下面积 (AUC) 0～ 2 4h( 3 3 84± 93 1) μg·L-1·h ,AUC0～∞( 3 845± 93 0 ) μg·L-1·h ,平均驻留时间 (MRT) ( 9.2 5± 1.3 5 )h ,消除半衰期 (T1/ 2 ) ( 8.68± 2 .85 )h。药物动力学特征表明该制剂口服后吸收较快 ,体内消除较慢 ,药物动力学参数个体间存在较大差异。
The plasma thiamazole level was determined by HPLC after a dose of 20 mg thiamazole orally in 12 male healthy volunteers. The main pharmacokinetic parameters are peak time (T max ) (1.52±0.96)h, peak concentration (C max ) (391±77)μg/L, area under curve (AUC) 0-24h (3384±931)μg·L -1 ·h, AUC 0-∞ (3845±930)μg·L -1 ·h, mean retard time (MRT)(9.25±1.35)h, half life of elimination (T 1/2 ) (8.68±2.85)h. The pharmacokinetic profile of thiamazole shows rapid absorption via gastrointestinal tract, slower elimination and a relatively wide individual variation in pharmacokinetic parameters.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2003年第2期148-149,共2页
Chinese Journal of Endocrinology and Metabolism
