8Pavco PA,Bouhana KS,Gallegos AM,et al. Anti-tumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors. Clin Cancer Res,2000,6(5) :2094-2103.
9Sandberg J, Sproul C, Btanchard K, et al Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targetingvascular endothelial growth factor receptor mRNA in the cynomolgus monkey Antisense Nucleic Acid Drug Der, 2000, 10(3) :153- 162.
10Asano M , Yukita A, Matsumoto T, et al. lnhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/ vascular permeability factor121. Cancer Res, 1995, 55(22) : 5296-5301.
2[1]Senger DR, Galli SJ, Dvorak AM, et al.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid [J]. Science, 1983; 219(4587)∶983
3[2]Connolly DT, Heuvelman DM, Nelson R, et al.Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis [J]. J Clin Invest, 1989; 84(5)∶1470
4[3]De Vries C, Escobedo JA, Ueno H, et al.The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor [J]. Science, 1992; 255(5047)∶989
5[4]Terman BI, Dougher-Vermazen NM, Carrion ME, et al.Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor [J]. Biochem Biophys Res Commun, 1992; 187(3)∶1579
6[5]Brock TA, Dvorak HF, Senger DR. Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells [J]. Am J Pathol,1991; 138(1)∶213
7[6]Namiki A, Brogi E, Kearney M, et al.Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells [J]. J Biol Chem, 1995; 270(52)∶31189
8[7]Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression [J]. Cancer Res,1995; 55(24)∶6161
9[8]McNamara DA, Harmey JH, Walsh TN, et al.Significance of angiogenesis in cancer therapy [J]. Br J Surg,1998; 85(8)∶1044
10[9]Samoto K, Ikezaki K, Ono M, et al.Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors [J]. Cancer Res,1995; 55(5)∶1189