摘要
3—氨基—1,2,4—三嗪化合物具有广泛的生理活性,如:治疗支气管扩张、抑制乳酸菌和疟原虫繁殖、杀菌等,因此,研究这类化合物的合成方法应运而生。常见的是由二羰基化合物,如:α,β—二酮、α—酮酸、α—
A new synthetic method of 3-amino-5-substituted phenylamino-6-phenyl-1,2,4-tria-
zines is reported in this paper. Benzoylthioformanilide was first condensed with aminoguani-
dine dihydrochloride in slightly acidic medium, then refluxed in alkaline medium (pH 8～9)
to give title compounds by the elimination of hydrogen sulfide. Nine 1,2,4-triazines were
synthesized by this reaction in good yields.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1992年第6期605-607,共3页
Chinese Journal of Organic Chemistry
关键词
氨基胍
氨基
三嗪
benzoyl thioformanilide
aminoguanidine
3-amino-1, 2, 4-triazine
