摘要
目的 :了解消化道肿瘤患者的抑郁状况及其影响因素 ,探讨患者细胞免疫功能变化 .方法 :用抑郁自评量表(self ratingdepressionscale ,SDS)等调查表对消化道肿瘤患者进行评定 ,同时测定外周血象、NK细胞 (CD5 6 )和T细胞亚群 .采用SPSS10 .0软件包统计 .结果 :10 8例患者SDS标准分范围为 33.8～ 6 6 .2分 ,有抑郁症状 (SDS≥ 5 0分 ) 5 4例 ,占 5 0 % .Cubic模型表明抑郁状况与焦虑正相关 ,与社会支持负相关 .多元线性逐步回归分析表明性欲降低、情绪沮丧、感觉不安、心跳加快、CD5 6和焦虑是消化道肿瘤患者抑郁症状的重要影响因素 .抑郁组外周血粒细胞数目增多 ,而CD3,CD4和CD8细胞百分率均下降 ,但CD4 /CD8比值变化不大 .CD5 6在抑郁组与非抑郁组之间有显著性差异 .结论 :抑郁是消化道肿瘤患者普遍存在的症状 ,受多种因素影响 ,抑郁患者细胞免疫功能低下 .
AIM: To determine the contributing factors of depressive symptoms and the changes of cellular immunity in patients with digestive tract neoplasm. METHODS: Self rating depression scale (SDS) and other questionnaires were used to evaluate the degree of depressive symptoms and the correlative factors. Immunological parameters,such as T lymphocyte subsets and natural killer (NK) cell activity in peripheral blood,were measured in 108 patients with cancers of the digestive tract. Initial data were analyzed by SPSS10.0. RESULTS: The range of SDS standard score was from 33.8 to 66.2. The cubic model showed that depression was positively correlated with anxiety and negatively correlated with social support. Half of the cases had depressive symptoms (SDS≥50). The step wise regression analysis suggested that decreased libido, dispiritment,agitation,palpitation, low CD56 and anxiety were important factors contributing to depressive symptoms.,In depression group, granulocytes increased, T lymphocyte subsets (CD3, CD4 and CD8) decreased but the CD4/CD8 ratio had little change, compared with those of the nondepression group. CD56 showed a significant decline in depression group ( P <0.05). CONCLUSION: Depressive symptoms, due to multiple complex factors, are common in patients with digestive tract neoplasm, who have decreased cellular immunity. Multiple interventions including psychological therapy are very important in relieving or precluding depressive symptoms and enhancing immunological function of the cancer patient.
出处
《第四军医大学学报》
CAS
北大核心
2003年第17期1627-1629,共3页
Journal of the Fourth Military Medical University
基金
陕西省自然科学基金 (99SM50 )
关键词
抑郁
消化道肿瘤
焦虑
社会支持
外周血象
NK细胞
T细胞亚群
depression
digestive tract neoplasm
anxiety
social support
peripheral blood
NK cell
T lymphocyte subsets
