摘要
目的:探讨超促排卵周期中血清血管内皮生长因子VEGF的动态变化以及VEGF在卵巢过度刺激综合征OHSS患者中的表达特征及是否具有预测价值。方法:选取行体外受精-胚胎移植治疗的不孕妇女分OHSS、高、中低反应组。收集各患者IVF周期中基础值、肌注人绒毛膜促性腺激素日(hCG日)、取卵日(OPU日)、移植日(ET日)及中、晚黄体期6个时点的血清和卵泡液,检测VEGF水平。结果:血清VEGF在超排卵周期中,各组从基础状态至中黄体期呈逐渐增高的趋势OHSS组中黄体期和晚黄体期显著升高,卵泡液VEGF水平亦明显高于另2组,中低反应组在各时点均显著低于另2组。结论:VEGF的表达与卵巢对超促排卵刺激的反应呈明显正相关,卵泡液VEGF水平可以预测OHSS的发生。
Objective: To investigate the VEGF levels throughout IVF cycles and to eveluate its forcast value for the syndrome. Method: Fortyone patients including OHSS group?high-responder group and low-moderate-responder group were enrolled prospectively from IVF-ET or ICSI program. Serum VEGF was assayed before godadotropin Gn, on the day of hCG administration, OPU, ET and after 7 and 14 days of ET. VEGF levels of follicular fluid (FF) were also assayed. Results: During IVF cycles, serum VEGF concentrations increased consistently till the day of ET, and those of low-moderate-responder group were all lower than those of other two groups. The difference was significant on mid luteal phase and late luteal phase between OHSS and high-responder group. FF VEGF concentration in OHSS group was higher than those of other two groups. Conclusion: VEGF levels have a positive correlation with the ovary's response to Gn during the IVF cycle. FF VEGF levels can be used to predict the occurrence of OHSS.
出处
《山东大学学报（医学版）》
CAS
2004年第1期89-91,95,共4页
Journal of Shandong University:Health Sciences
基金
山东省卫生厅科研基金资助项目(1999CAIDBAS)
关键词
卵巢过度刺激综合征
血管内皮生长因子
超排卵
Ovarian hyperstimulation syndrome
Vascular endothelial growth factor
Hyperinstimulation ovulation
