摘要
目的:研究血清血管紧张素转换酶(angiotensin-convertryenzyme,ACE)活性在脑梗死及血管性痴呆患者血清中的水平及与脑功能的相关性。方法:采用毛细管电泳法测定47例血管性痴呆(vasenlardisese,VD)患者、43例脑梗死患者、30例健康对照者(HC)血清ACE活性。结果:与健康受试者(22.62±5.44)μmol/(min·L)比较,脑梗死患者血清ACE活性(19.26±5.11)μmol/(min·L)显著降低(t=2.32,P<0.05),尤其是伴发高血压患者(18.42±5.20)μmol/(min·L)及男性患者(19.71±4.99)μmol/(min·L);而VD患者血清ACE活性(21.95±7.19)μmol/(min·L)虽亦稍低于脑梗死受试者,但无统计学意义。结论:脑梗死可致血清ACE活性降低,与脑组织损伤程度有关,与脑功能状态有关。
AIM:To study the association of serum angiotensin converting enzyme(ACE) activity in cerebral infarction and vascular dementia with brain function. METHODS:The serum ACE activity in 47 cases of vascular dementi(VD),43 cases of cerebral infarction(CI) and 30 health controls were measured by means of capillary electrophoresis-ultraviolet detection. RESULTS:Compared with the health controls[(22.62±5.44)μmol/(min·L)],the serum ACE activity was significantly lower in the CI patients [(19.26±5.11)μmol/(min·L)](t=2.32,P< 0.05),especially in those patients with hypertension[(18.42±5.20)μmol/(min·L)]and male ones[(19.71±4.99) μmol/(min·L)].The serum ACE activity in the VD patients was(21.95±7.19) μmol/(min·L),slightly lower than that in the normal controls, but significant difference was not found between the two groups. CONCLUSION:The serum ACE activity decreases in the event of cerebral infarction,which is related with the degree of cerebral tissue damage and the state of brain function.
出处
《中国临床康复》
CSCD
2004年第7期1235-1237,共3页
Chinese Journal of Clinical Rehabilitation
基金
江苏省科技厅应用基础研究项目(1998年)资助(BJ98092)~~
