摘要
香豆素是一种用途广泛的香料,虽然已有多种合成方法,但国内仍采用以水杨醛为原料的路线(产率为60%左右),提高产率是改进其合成工艺的关键。我们曾以氟化钠代替乙酸钠作催化剂,以水杨醛和乙酐为原料合成了香豆素,提高了产率。
The synthesis of coumarin has been improved with good yield by yarying the adding order of the starting materials and using polyethylene glycol as phase transfer catalyst. Optimum molar ratios were salicylaldehyde: acetic anhydride: potassium acetate=1:3.7:0.5 and salicylaldehyde:acetic anhydride:potassium fluoride=1:3.7:0.35.
出处
《应用化学》
CAS
CSCD
北大核心
1992年第3期79-82,共4页
Chinese Journal of Applied Chemistry
关键词
香豆素
氟化钾
相转移催化
合成
coumarin, polyethlene glycol, potassium fluoride, potassium acetate, phase transfer catalysis
