摘要
The relationship between 3 polymorphisms sites[interleulin-4(IL-4),IL-4 receptor(IL-4R)αchain and activation-induced cytidine deaminase(AICDA)]and adult allergic asthma in China was studied.By using case-control method,DNA and clinical data were obtained from allergic asthmatic patients and compared with those in the control subjects.The subjects were genotyped for the IL-4 C-589T promoter polymorphism,the IL-4Rαchain Q576R and the AICDA C8408T by poly-merase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method.The results showed that the IL-4 C-589T was not associated with adult allergic asthma in China.However,the IL-4Rαchain 576R/R and AICDA 8408T/T frequency was significantly increased in allergic asthma group as compared with that in the control group[odd ratio(OR)=3.797 and 9.127,respectively;P<0.01)]and was correlated with the increased plasma total IgE.These data suggested that the IL-4Rαchain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergic asthma in China.
