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美托拉宗的NMR数据解析 被引量：2

A NMR STUDY OF METOLAZONE
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摘要 对美托拉宗进行了~1H和^(13)C MNR检测,通过DEPT和HMQC、HMBC等2D NMR技术对其~1H和^(13)C NMR数据进行了全归属和详细的解析,并指出其NMR数据特征。 Metolazone is a well-known quinazolinone diuretic widely used for the treatment of congestive heart failure and high blood pressure. Metolazone was first synthesized in 1967 with its first detailed pharmacological evaluation done in 1969. Previous results only reported part of its ~1H NMR data, and the detailed elucidation is yet to be performed. In this paper, using a combination of 1D and 2D NMR techniques, the ~1H and ^(13)C NMR spectra of metolazone were completely assigned and analyzed. The characteristics of its NMR data were also discussed.
作者 董建军 吴鸣建 张海艳 付经国 陈涛 赵天增
机构地区 河南省生物技术开发中心 西安力邦企业
出处 《波谱学杂志》 CAS CSCD 北大核心 2004年第1期93-97,共5页 Chinese Journal of Magnetic Resonance
关键词 美托拉宗 核磁共振 构象异构体 利尿剂 结构分析 分子结构 NMR, metolazone, conformational isomer
分类号 R917 [医药卫生—药物分析学] O482.532 [理学—固体物理]
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参考文献12

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同被引文献14

  • 1张海艳,吴鸣建,董建军,付经国,陈涛,赵天增.地塞米松棕榈酸酯的NMR数据解析[J].波谱学杂志,2004,21(4):405-411. 被引量：8
  • 2张俊,武岳,杨雪艳,吴范宏,张可可.氟西汀盐酸盐合成路线图解[J].中国医药工业杂志,2005,36(4):253-255. 被引量：3
  • 3黄彦合,王礼琛,黄嘉梓.抗抑郁药氟西汀的合成[J].中国药物化学杂志,1996,6(1):56-58. 被引量：10
  • 4狄平平,徐远,张圩.盐酸氟西汀化学结构确证及其理化性质的研究[J].中国医药工业杂志,1996,27(7):317-319. 被引量：3
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  • 6Devine P N,Heid R M,Tschaen Jr D M.Stereoselective synthesis of 2-aryloxy esters:an asymmetric approach to fluoxetine,tomoxetine and nisoxetine[J].Tetrahedron,1997,53(20):6739-6746.
  • 7Kumer P,Upadhyay R K,Pandey R K.Asymmetric dihydroxylation route to (R)-norfluoxetine and (R)-fluoxetine[J].Tetrahedron-Asymmetr,2004,15:3 955-3 959.
  • 8Robbins D K,Dodson P N,Buccilli L A,et al.Utilizing capillary gas chromatography mass spectrometry to determine 4-benzotrifluoride t-butyl ether as a reaction by-product in fluoxetine synthesized using potassium t-butoxide as base[J].Journal of Pharmaceutucal and Biomedical Analysis,2003,31:63-74.
  • 9MULLIKEN R S. Structures of complexes formed by halogen molecules with aromatic and with oxygenated solvents[J]. J Am Chem Soe, 1950,72(1) :600-608.
  • 10郭福庆.荷移分光光度法及其在抗生素药物分析中的应用[J].天津药学,2008,20(1):61-64. 被引量：5

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波谱学杂志
2004年 第1期

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