摘要
目的 评价骨肉瘤患者术前血清ALP、LDH水平与预后的相关性。方法 1989—1999年入院手术的65例ⅡB期肢体骨肉瘤患者,所有病例经过3～13年随访,平均7.6年。回顾性分析患者术前ALP、LDH与复发率、无瘤生存率。结果 ALP、LDH升高组患者复发率较高、无瘤生存率低,较对照组有显著性差异,尤以LDH组差异明显。ALP、LDH两指标吻合度较强。结论 骨肉瘤患者术前ALP、LDH水平可反映其预后,LDH值作为预后的检测指标较ALP更有特异性。
Purpose: To explore the prognostic significance of preoperative serum alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in osteosarcoma patients. Methods: We performed a retrospective analysis of 65 patients with non-metastatic limb osteosarcoma that were treated Between 1989 and 1999. Thirty-eight of them were male and twenty-seven were female. They were followed-up for 3-13 years (mean seven years and six months). Results: The ALP and LDH levels at diagnosis showed significant correlation with prognosis. Disease-free survival (DFS) was 25% in patients with ALP levels>200 IU/L, and 62.1% in patients with ALP levels0.001). Conclusions: These data demonstrate that in osteosarcoma of limb pretreatment ALP and LDH have a prognostic value. LDH is more specific than ALP as a prognostic indicator.
出处
《复旦学报（医学版）》
EI
CAS
CSCD
北大核心
2004年第1期87-89,共3页
Fudan University Journal of Medical Sciences
