摘要
介绍了维生素B_2、维生素K_3、磺胺嘧啶锌和维那利酮4种固体药物在自然光及灯光下的稳定性,探讨了不同光源对药物稳定性影响的等效关系。由此可使以不同光源研究药物稳定性所得之结果能相互换算,并可用灯光为光源研究药物在自然光下的稳定性。 上述4种药物的表面反射率R与各光源的光照量Et之间的关系都可用经验式R=A+B(Et)十C/(Et+D)准确地表达,并可用本文介绍的方法对不同光源的光照量进行等效换算。
The photostability of vitamin B_2, vitamin K_3, zinc sulfadiazine andvesnarinone, and the equivalent influences of different light sources on the photostability ofthe above drugs were studied under natural light and lamp lights. From this study, thephotostability of drugs under different light sources can be converted to each other, and thenatural light photostability of drugs can be conveniently,obtained from lamp light exposureexperiments. The relationship between the surface reflectance of the above drugs and the cumulativeillumination of different light sources can be formulized as R=A+B(Et) + C/( Et+ D)accurately, and the cumulative illumination of different light sources irradiated on theabove drugs can be converted to each other equivalently.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第7期544-548,共5页
Acta Pharmaceutica Sinica
关键词
光稳定性
自然光
灯光
药物
Photostability
Natural light
Lamp light
Reflectance
