摘要
给成年SHRsp分别ip间硝苯啶2.5,5及10mg·kg^(-1)后昀显著降低血压,1h达高峰,分别维持2～4,6～8及12h。降压幅度及维持时间均大于等剂量的硝苯啶。慢性实验分别用间硝苯啶10及30mg·kg^(-1)·d^(-1)po给药4周,治疗后降压作用比溶媒对照组强,但与等量硝苯啶无明显差异。
Three groups of adult stroke-prone spontaneously hypertensive rats(SHRsp) were treated with m-nifedipine(m-Nif)2. 5, 5 and 10 mg ·kg^(-1) byintraperitoneal injection. The systolic blood pressure (SBp) decreased significantly. Thehypotensive effect persisted for 2 ～4,6 ～8, and 12 h respectively and the peak effect ap-peared in 1 h. The range of hypotension was markedly greater than that of nifedipine(Nif). In SHPsp, treatment with m -Nif 10 or 30 mg·kg(-1)·d^(-1) for 4 weeks reducedsignificantly the SBp, but the hypotensive action is about the same as Nif.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第3期170-172,共3页
Acta Pharmaceutica Sinica
关键词
间硝苯啶
降压作用
降压药
m--Nifedipine
Antihypertensive action
