摘要
以腹腔注射法对蟾蜍 (Bufogargarizans)给镉 (按动物体重的质量分数分别给 0 .1mgkg-1,0 .2mgkg-1,0 .4mgkg-1,0 .8mgkg-1的Cd) ,处理 7d后 ,测定其肝、肾丙二醛 (MDA)、谷胱甘肽 (GSH)含量及超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GSH PX)、谷胱甘肽 S转移酶 (GSH ST)的活性 .结果显示 ,一定浓度的镉能引起肝、肾MDA含量明显增加 ,而GSH含量及SOD、CAT、GSH ST酶的活性则显著下降 .提示一定浓度的镉能引起蟾蜍肝、肾组织脂质过氧化损伤 ,使蟾蜍肝、肾抗氧化能力、抗诱变能力降低 ;脂质过氧化损伤可能与GSH的耗竭、抗氧化酶SOD、CAT等酶活性的降低有关 .图 6参
Different doses of cadmium nitrate [w(Cd)/mg kg -1:0.1,0.2,0.4,0.8] were administrated to the adult Bufo Gargarizans. After 7 days′ treatment, the effect of Cd 2+ on the contents of malondialdehyde (MDA) , glutathione(GSH) and the activities of superoxide dismutase (SOD),catalase (CAT), glutathione peroxidase (GSH-PX), and glutathione sulfatransferase (GSH-ST) were observed. The results showed that the contents of MDA in liver and kidney increased significantly, but those of GSH and the activities of SOD ,CAT and GSH-ST in liver and kidney decreased significantly. The results suggest that Cd 2+ induce lipid peroxidation in liver and kidney, and the decrease of GSH and the capacity of antioxidase (SOD,CAT) be considered as the cause of lipid peroxidation. Fig 6, Ref 16
出处
《应用与环境生物学报》
CAS
CSCD
2004年第1期92-94,共3页
Chinese Journal of Applied and Environmental Biology
基金
浙江省自然科学基金资助项目 (No :30 2 0 56)~~
关键词
镉
蟾蜍
肝
肾
脂质过氧化损伤
Cadmium
lipid peroxidation
liver
kidney
Bufo gargarizans
