摘要
在对视网膜母细胞瘤病人的Rb 基因存在状态进行检测时,发现一例患者体细胞Rb 基因有明显扩增改变。Rb 基因在视网膜母细胞瘤患者中的扩增改变,为首次报导,是否意味着Rb 基因扩增与肿瘤发生有着某种关联。
We found the change of proliferation with 6.2kb Hind ⅠⅡ fragment of Rb gene inretinoblastoma while the Rb gene was detected.The existence of proliferation of Rb genein retinoblastoma is first reported by us.It is contrary to the current theory that Rb geneis an antioncogene and the deletions of Rb gene is responsible for the tumorigenesis ofretinoblastoma.It is possible that the proliferation of Rb gene plays an important rolefor the tumorigenesis,so we discuss the finding preliminarily
出处
《眼科研究》
CSCD
1992年第2期125-127,共3页
Chinese Ophthalmic Research
