摘要
目的 评价LFTP方案治疗晚期胃癌的疗效、毒副作用。方法 吡喃阿霉素 (THP) 45mg/m2 静点 ,第 1天 ,顺铂 (CDDP) 2 0mg/m2 静点 ,第 1～ 5天 ,亚叶酸钙 (LV) 10 0mg/d静点 ,2小时后接 5_氟脲嘧啶 ( 5_Fu) 60 0mg/m2 静点 8小时 ,第 1～ 5天 ,2 1天为 1个周期。结果 3 9例中CR 3例 ( 7 7% ) ,PR 17例 ( 4 3 6% ) ,近期有效率 (ORR) 5 1 3 % ,中位无进展生存期 (mTTP) 5个月 ,本方案剂量限制性毒性为骨髓抑制 ,Ⅲ、Ⅳ度为 4例 ( 10 3 % ) ,胃肠道反应Ⅲ度 1例 ( 2 6% ) ,无化疗相关性死亡。结论 LFTP方案治疗晚期胃癌疗效较好 ,毒副反应可以耐受 ,有临床应用价值。
Objective To study the efficacy and the toxicity of combination chemotherapy including Pirarubicin, Leucovorin,5_Fluorouracil, Cisplatin for advanced/metastatic gastric carcinoma.Methods THP 45 mg/m 2 iv d1,CDDP 20 mg/m 2 iv d1_5 ,LV 100 mg/d iv 2h followed by 5_Fu 600 mg/m 2 iv 8h d1_5, repeat every three weeks.Results Thirty nine patients have been entered the study, these patients achieved CR(7.7%) ,17PR(43.6%),ORR51.3%,median time to progress(mTTP) was 5 months, the dose limiting toxicity was myelosuppression,with Grade 3+4 in 4 patients(10.3%), nausea in 1 patient (2.6%).Conclusion These results suggested that LFTP regimen was well tolerated and effective for advanced/metastatic gastric carcinoma.
出处
《河南肿瘤学杂志》
2004年第1期35-36,共2页
Henan Journal of Oncology
