摘要
目的 探讨胰岛素样生长因子 1受体 (IGF 1R)在乳腺癌组织和正常乳腺组织中的分布和表达。方法 采用免疫组织化学方法 ,对乳腺癌组织和正常的乳腺组织中IGF 1R的表达情况进行检测分析。结果 乳腺癌组织中IGF 1R的阳性表达率均明显较正常乳腺组织高 (P <0 .0 5 )。结论 由此推断 ,IGF 1R在乳腺癌发生发展过程中发挥着重要作用。IGF 1R有可能成为临床乳腺癌诊断和判断预后的一个重要指标。
Objective to evaluate the distributing and expression of insulin-like growth factor-1 receptor of breast cancer and normal breast tissue. Methods The IGF-1R expression on breast cancer and normal breast tissue was tested by immunohistochemistry. Results The positive rate on the breast cancer was higer than it on the normal breast tissue(P<0.05). Conclusions These data suggested that IGF-1R play an important role in pathogenesis and development of breast cancer. IGF-1R may be a adjuvant index for diagnosing to breast cancer and estimating prognosis.
出处
《河南肿瘤学杂志》
2004年第1期1-2,F003,共3页
Henan Journal of Oncology
